"Fathers and Sons" revolves around the intertwined tales of three families who grow up on the same street, focusing on the relationship of fathers and sons.

The first section, directed by Spera, features Anthony (Whitford) and Jenny (Mathis) and traces the father-son bond that develops between Anthony and his
newborn son over 30 years.

The second story, helmed by Garcia, centers on the affairs of an airline pilot (Mahoney) who shares a house but not a life with his wife (Baker). He crosses
paths with an unusual woman (DuVall) and spends an extraordinary night with his son (Eldard).

The final chapter, with Rappaport at the helm, follows the homecoming of Elliot (Harold) to his estranged family (Barbara Barrie, Joe Bologna and Lisa Edelstein). As his father dies, Elliot meets and falls in love with a woman (Shaw) who sees past his tough-guy exterior.